Bioactive Small Molecules
Selleck Chemical LLC Rucaparib | 283173-50-2 | MFCD11977252 | 5 mg
Rucaparib | Purity: 99% | Mol Wt: 323.369 | 283173-50-2 | MFCD11977252 | 5 mg *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Demecarium Bromide S9463-100MG
Demecarium Bromide an anticholinesterase is an inhibitor of monoamine oxidase (MAO) It induces long-term miosis and decreases intraocular pressure (IOP) in normotensive eyes of Beagles and of eyes of Beagles with inherited glaucoma
Selleck Chemical LLC Lazertinib S8724-25MG
Lazertinib (YH25448 GNS-1480) is a potent highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1 7 nM 2 nM 5 nM 20 6 nM and 76 nM for Del19/T790M L858R/T790M Del19 L85R and Wild type EGFR respectively showing much higher IC50 values aganist ErbB2 and ErbB4
Selleck Chemical LLC Mecamylamine Hydrochloride S9459-5MG
Mecamylamine hydrochloride is an orally active nonselective noncompetitive nAChR(nicotinic acetylcholine receptors) antagonist It is also a ganglionic blocker and can across the blood-brain barrier It can be used in the research of neuropsychiatric disorders hypertension antidepressant area
Selleck Chemical LLC Basimglurant E4619-100MG
Basimglurant(RG7090 CTEP Derivative) is a potent and selective negative allosteric modulator of mGlu5 with a Kd of 1 1 nM It inhibits the function of mGluR5 thereby regulating glutamatergic neurotransmission
Selleck Chemical LLC BBC0403 E4713-1G
BBC0403 is a small-molecule selective inhibitor of Bromodomain-containing protein 2(BRD2) with Kds of 7 64 M and 41 37 M for BRD2 (BD2) and BRD2 (BD1) respectively It is a potential intra-articular injectable therapeutic agent for treating osteoarthritis (OA)
Medchemexpress LLC HY-15162 10mg Medchemexpress, Monomethyl auristatin E CAS:474645-27-7 Purity:>98%
Medchemexpress, HY-15162 10mg Monomethyl auristatin E CAS:474645-27-7 Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC Tamarixetin E2502-5MG
Tamarixetin (4 -O-Methyl Quercetin) is a natural flavonoid derivative of quercetin and has superior anti-inflammatory properties in bacterial sepsis by increasing the population of IL-10-secreting immune cells
Apexbio Technology LLC Golvatinib (E7050), 10mg. Cas: 928037-13-2 MFCD: MFCD22124462. C-Met/VEGFR-2 inhibitor
Golvatinib is an inhibitor of c-Met and VEGFR-2 tyrosine kinase with IC50 values of 14nM and 16nM, respectively [1].The small molecule compound, golvatinib, is a dual inhibitor of both c-Met and VEGFR-2. Other sizes are available. Please inqury us for quote.
Medchemexpress LLC CD19 Mouse Biotiny 50ug | 50ug
The CD19 protein acts as a coreceptor for B cell antigen receptors lowering the signaling threshold and initiating B cell responses to antigens It activates a cascade leading to PI3K activation and Ca(2 ) mobilization CD19 Protein Mouse (Biotinylated HEK293 His) is the recombinant mouse-derived CD19 protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC Lifitegrast impurity 4 (hydrochloride) | 2049127-88-8 | 25g
Lifitegrast impurity 4 hydrochloride is an impurity of Lifitegrast (HY-19344)
Cayman Chemical ANTIBODY Scoparon 10mg
A coumarin with diverse biological activities; inhibits angiotensin II-induced ECM remodeling and cell proliferation and reduces levels of collagen I and fibronectin in isolated primary neonatal rat cardiac fibroblasts from 1-10 µM; suppresses PDGF-BB-induced RASMC migration and wound healing in a scratch assay; reduces vascular neointima formation in a rat model of carotid artery balloon injury at 3.5 mg/kg; reduces hepatocyte apoptosis, liver fibrosis, serum levels of ALT and AST, and hepatic triglyceride levels in a mouse model of MCD-induced NASH; reduces ulcer lesion area in a rat model of HCl- and ethanol-induced gastric ulcers; inhibits passive cutaneous anaphylaxis in rats
Cayman Chemical ANTIBODY KT172 50mg
A non-selective inhibitor of DAGLα and DAGLβ; inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol in HEK293T cell membranes expressing recombinant DAGα or DAGLβ (IC50s = 140 and 60 nM, respectively); inhibits ABHD6 (IC50 = 5 nM) and weakly inhibits MAGL (IC50 = 5,000 nM) in a panel of 47 mouse serine hydrolases (IC50s = 5 and 5,000 nM, respectively); restores nicotine-stimulated GABA release in isolated VTA dopamine neurons from rats chronically exposed to nicotine at 1 µM; decreases production of 2-arachidonoyl glycerol and subsequently reduces arachidonic acid, PGE2, and PGD2 in thioglycolate-stimulated peritoneal macrophages at 5 mg/kg in mice.
Medchemexpress LLC Neridronate | 79778-41-9 | 98.0% | 25 MG
Neridronate is an aminobisphosphonate research chemical used to study bone metabolism and bisphosphonate pharmacology. Supplied as a white to off-white solid, it is intended for laboratory research use only and not for clinical or veterinary applications.
- Purity 98.0%
- Pack size 25 MG
- Molecular formula C6H17NO7P2
- Molecular weight 277.15 g/mol
- Appearance white to off-white solid
- CAS number 79778-41-9
Medchemexpress LLC GSK-3β inhibitor 2 | 1702428-31-6 | ≥95.0% | 318.35 g/mol | C14H14N4O3S | 5 MG
GSK-3β inhibitor 2 is a potent, selective, and orally active inhibitor of glycogen synthase kinase-3β (GSK-3β) with an IC50 of 1.1 nM. It is reported to cross the blood-brain barrier and is used in preclinical research to probe GSK-3β-mediated signaling pathways. The compound is supplied as a powder; molecular formula C14H14N4O3S and molecular weight 318.35 g/mol.
- Potent and selective GSK-3β inhibition (IC50 1.1 nM).
- Demonstrated blood-brain barrier penetration.
- Suitable for in vitro and in vivo preclinical studies.
- Provided as a powder for solution preparation.
- Molecular formula C14H14N4O3S; molecular weight 318.35 g/mol.