Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,226 – 6,240 of 60,541 results

6,226

Selleck Chemical LLC NLRP3/AIM2-IN-3 E5801-25MG

NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with species-specific effects on NLRP3 and AIM2 inflammasome-mediated pyroptosis It demonstrates potent inhibition of pyroptosis in THP-1 macrophages stimulated with LPS/nigericin with an IC50 of 0 077 M It also disrupts the interaction between NLRP3 or AIM2 and the adaptor protein ASC effectively preventing ASC oligomerization and blocking inflammasome assembly

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6,227

Cayman Chemical Isoorientin, Purity: ≥95%, CAS: 4261-42-1, 5 mg

A flavonoid with diverse biological activities; induces apoptosis in and reduces cell viability of PATU-8988 and PANC-1 pancreatic cancer cells; reduces expression of COX-2, IL-6, 5-LO, and TNF-α in RAW 264.7 cells; reduces carrageenan-induced paw edema and air pouch blood vessel swelling in mice at 20 mg/kg; increases stomach levels of SOD and GSH and reduces ulcer area in a rat model of indomethacin-induced gastric ulcers

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6,228

Cayman Chemical AA3-DLin, Purity: ≥95%, CAS: 3027565-91-6, 25 mg

An ionizable cationic amino lipid (pKa = 5.8); has been used in combination with other lipids in the formation of LNPs for mRNA delivery; LNPs containing AA3-DLin and encapsulating SARS-CoV-2 spike glycoprotein mRNA induce immunogenicity in mice

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6,229

Medchemexpress LLC MDA 19 (BZO-HEXOXIZID) | 1048973-47-2 | C21H23N3O2 | 50 MG

MDA 19 is a potent and selective agonist of human cannabinoid receptor 2 (CB2), with a Ki of 43.3 nM. It exhibits antiallodynic effects in a rat model of neuropathic pain and does not affect rat locomotor activity.

Potent and selective agonist of human cannabinoid receptor 2 (CB2)
Exhibits antiallodynic effects in a rat model of neuropathic pain
Does not affect rat locomotor activity
Higher affinity at human CB2 (Ki = 43.3 nM) than human CB1
Nearly 70-fold higher affinity at rat CB2 (Ki = 16.3 nM) than rat CB1

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6,230

Cayman Chemical ML-792, Purity: ≥98%, CAS: 1644342-14-2, 5 mg

An inhibitor of SUMO-activating enzyme (IC50s = 0.003 and 0.011 µM with SUMO1 or SUMO2, respectively, as the ubiquitin-like proteins); selective for SAE over NAE and UAE (IC50s = 32 and >100 µM, respectively); decreases global SUMOylation in HCT116 cells (EC50 = 0.019 µM), as well as decreases the viability of MDA-MB-468 and A375 cells (EC50s = 0.06 and 0.45 µM, respectively); reduces tumor growth in an HCT116 mouse xenograft model at 150 and 200 mg/kg twice per day

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6,231

Cayman Chemical Bromantane, Purity: ≥98%, CAS: 87913-26-6, 25 mg

An analytical reference standard categorized as a stimulant; has been used to enhance physical performance in athletes; intended for research and forensic applications

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6,232

Medchemexpress LLC GNE-149 | 1953132-75-6 | 99.2% | C28H33F4N3O | 25 MG

GNE-149 is an orally bioavailable full antagonist of estrogen receptor α (ERα) and a selective estrogen receptor degrader (SERD). It can be used for breast cancer research, exhibiting antiproliferative activity in MCF7 and T47D cells, and inducing ERα degradation. It also demonstrates efficacy in an MCF7 xenograft mouse model.

Full antagonist of estrogen receptor α (ERα)
Selective estrogen receptor degrader (SERD)
Exhibits antiproliferative activity in MCF7 and T47D cells
Induces ERα degradation
Favorable pharmacokinetic profile with oral bioavailability in various models
Solid, white to light yellow appearance

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6,233

Cayman Chemical Olanzapine, Purity: ≥98%, CAS: 132539-06-1, 100 mg

An atypical antipsychotic; binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as 5-HT2A, 5-HT2C, and 5-HT3 receptors (Kis = 4, 11, and 57 nM, respectively); binds to M1 muscarinic acetylcholine, α1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively); decreases immobility time in the forced swim test in non-stressed and prenatally-stressed rats at 0.5 mg/kg; decreases the number of avoidances made in the conditioned avoidance response test in rats at 0.5 and 1 mg/kg

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6,234

Medchemexpress LLC Methacrylic acid N-h 250mg

Methacrylic acid N-hydroxysuccinimide ester (NHS-MA) ios used as a monomer to prepare degradable amphiphilic block copolymer microparticles via RAFT polymerization for low pH-triggered drug delivery[1]

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6,235

Selleck Chemical LLC Biotin-PEG3-azide E7219-5MG

Biotin-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs Biotin-PEG3-azide is a click chemistry reagent it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups

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6,236

Cayman Chemical iCRT14, Purity: ≥98%, CAS: 677331-12-3, 5 mg

An inhibitor of CRT (IC50 = 40.3 nM); inhibits β-catenin/Tcf4 binding (Kis = 53.51 μM); inhibits Notch, Hh, and JAK/STAT signaling (IC50s = 69.2, 194, and 70 nM, respectively); reduces proliferation and initial tumor growth rate in mouse xenografts of colon carcinoma (50 mg/kg i.p.); inhibits proliferation of leukemia cell lines; suppresses ATP-driven migration of the MCF-7 and MDA-MB-231 breast cancer cell lines

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6,237

Medchemexpress LLC HY-136244 5mg Medchemexpress, PF-06952229 CAS:1801333-55-0 Purity:>98%

Medchemexpress, HY-136244 5mg PF-06952229 CAS:1801333-55-0 PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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6,238

Cayman Chemical Chebulagic Acid, Purity: ≥98%, CAS: 23094-71-5, 5 mg

A polyphenol and tannin with diverse biological activities; an inhibitor of COX-1, COX-2, and 5-LO (IC50s = 15, 0.92, and 2.1 μM, respectively) as well as α-glucosidase and 15-LO (IC50s = 0.05 and 24.9 μM, respectively); inhibits LPS-induced increases in iNOS, COX-1, COX-2, and 5-LO protein levels, production of NO, PGE2, and ROS, and nuclear translocation of NF-κB in RAW 264.7 macrophages; inhibits the growth of HCT15, COLO 205, MDA-MB-231, DU145, and K562 cancer cells (GI50s = 20.3, 18, 26.2, 28.54, and 30.66 μM, respectively); increases insulin-stimulated glucose uptake in 3T3-L1 adipocytes; scavenges DPPH radicals (IC50 = 1.4 μM); exhibits antiviral activity against cytomegalovirus, hepatitis C virus, dengue virus, measles virus, and respiratory syncytial virus in vitro (EC50s = 25.5, 12.16, 13.11, 34.42, and 0.38 μM, respectively)

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6,239

Medchemexpress LLC KH-CB19 | 1354037-26-5 | 99.3% | 1 ML

KH-CB19 is a potent inhibitor of cdc2-like kinase (CLK), specifically targeting CLK1 with an IC50 of 19.7 nM and CLK3 with an IC50 of 530 nM. It also exhibits antiviral activity, inhibiting influenza virus replication with an IC50 of 13.6 μM. This compound is valuable as a research tool to study the regulation of alternative splicing.

Potent CLK inhibitor
Exhibits antiviral activity
Purity of 99.3%
Appears as a white to light yellow solid
Soluble in DMSO (≥ 50 mg/mL)
Molecular weight is 338.19
Can be stored as powder at -20°C for 3 years or 4°C for 2 years
Can be stored in solvent at -80°C for 2 years or -20°C for 1 year

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6,240

Cayman Chemical Tasimelteon-d5, Purity: ≥99% deuterated forms (d1-d5), CAS: 1962124-51-1, 5 mg

An internal standard for the quantification of tasimelteon by GC- or LC-MS

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Bioactive Small Molecules

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Medchemexpress LLC MDA 19 (BZO-HEXOXIZID) | 1048973-47-2 | C21H23N3O2 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC GNE-149 | 1953132-75-6 | 99.2% | C28H33F4N3O | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Methacrylic acid N-h 250mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-136244 5mg Medchemexpress, PF-06952229 CAS:1801333-55-0 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC KH-CB19 | 1354037-26-5 | 99.3% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MDA 19 (BZO-HEXOXIZID) | 1048973-47-2 | C21H23N3O2 | 50 MG

Medchemexpress LLC GNE-149 | 1953132-75-6 | 99.2% | C28H33F4N3O | 25 MG

Medchemexpress LLC Methacrylic acid N-h 250mg

Medchemexpress LLC HY-136244 5mg Medchemexpress, PF-06952229 CAS:1801333-55-0 Purity:>98%

Medchemexpress LLC KH-CB19 | 1354037-26-5 | 99.3% | 1 ML